P-46 GIT carcinoids and the risk of multiple primary GIT tumors

Carcinoid tumors are rare neuroendocrine with slowly progressive course. the most common gastrointestinal (GI) tumors. The sites of GI carcinoids small intestine accounting for 45%, rectum (20%), appendix (17%), colon (11%), and stomach (7%). Some studies reported an association between multiple malignancies. However, presence combined primary is considered exotic event in literature only few case series. So aim this study to assess risk synchronous metachronous malignancies following carcinoids. We analyzed data from cancer registries participating Surveillance, Epidemiology, End Results (SEER) software patients diagnosed carcinoid tumor malignant behavior 2000-2019 .Standardized incidence ratios (SIR) was assessed as observed/expected (O/E) excess absolute (EAR) per 10,000 person-years calculated using SEER-specific outcome analysis. 95% SIR confidence intervals were statistical significance achieved at P < 0.05. There 1351 first GIT developed 2nd O/E ratio 2.17 (Expected=621, EAR=27.53,P 0.05). Patients have two folds increased while gastric significantly up 7 than other which 5 2-11months interval 8 years interval. As indolent disease course leading late diagnosis, we recommend screening once paying more attention continuous follow every 6 months.